Abstract
In a study of intravenous catheterization in 150 patients, the application of nitrofurazone-treated pads at the site of catheter entry was associated with an incidence of catheter tip infection significantly lower than that associated with nonmedicated pads. Species analysis indicated that bacterial phlebitis caused by S aureus occurred less often in the treated group than in the controls. Erythema, noted at twenty-six venipuncture sites, did not correlate specifically with positive bacterial cultures from the catheter tip thrombus. The administration of potassium chloride solutions via the catheter, however, was associated with a significantly higher incidence of erythema than that which occurred with the administration of other fluids. There was no correlation between the incidence of positive catheter tip cultures and the use of either potassium chloride or systemic antibiotics. No instance of septicemia, suppurative phlebitis, or hypersensitivity reaction to nitrofurazone was observed.
Published Version
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