Abstract
The bactericidal activity of 21 plant extracts on Helicobacter pylori was investigated. Plants were boiled in water to produce aqueous extracts. Bactericidal activity of the extracts was assessed by a standard kill-curve using five strains of H . pylori isolated from Sri Lanka and the NCTC 11637 strain. Among the plants that showed bactericidal activity for H.pylori, turmeric and ginger were the most efficient followed by chilli and black tea. Nutmeg, liquorice, cinnamon, colombo weed, yellow-berried nightshade, threadstem carpetweed, sage, parsley, long pepper, and cumin also showed bactericidal activity against H. pylori. These could serve as potent alternative therapies for H. pylori infection, avoiding the problem of resistance associated with current antibiotic treatment. Keywords: Bactericidal effect, ginger, Helicobacter pylori , inhibition, medicinal, plants, Sri Lanka, turmeric doi:10.4038/jnsfsr.v36i1.135 Journal of the National Science Foundation of Sri Lanka 36 (1) 91-94
Highlights
Helicobacter pylori is a strict human pathogen which has colonized half the world population[1]
Bactericidal activity of the extracts was assessed by a standard kill-curve using five strains of H. pylori isolated from Sri Lanka and the NCTC 11637 strain
Liquorice, cinnamon, colombo weed, yellow-berried nightshade, threadstem carpetweed, sage, parsley, long pepper, and cumin showed bactericidal activity against H. pylori. These could serve as potent alternative therapies for H. pylori infection, avoiding the problem of resistance associated with current antibiotic treatment
Summary
Helicobacter pylori is a strict human pathogen which has colonized half the world population[1]. The overall data for the prevalence of H. pylori in Sri Lanka differ from 3-70 % and seems to correspond more to that of an industrialized country[7,8]. The reason for the low prevalence of H. pylori in Sri Lanka is an enigma. One of the reasons for the low prevalence may be the Sri Lankan diet. A study in the UK used Italian strains of H. pylori to test the bactericidal activity of spices, tea and medicinal plants. The results of the study demonstrated inhibitory action in some of the tested plants extracts[6]. The genetic composition of H. pylori strains differ in various geographic regions of the world[6] and this study was designed to determine the inhibitory effects of certain spices, medicinal plants and tea against H. pylori strains isolated from Sri Lanka
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