Abstract
PurposeTo investigate the antibacterial effect and the effect on the material properties of a novel delivery system with Irgasan as active agent and methacrylated polymerizable Irgasan when added to experimental dental resin composites.Materials and MethodsA delivery system based on novel polymeric hollow beads, loaded with Irgasan and methacrylated polymerizable Irgasan as active agents were used to manufacture three commonly formulated experimental resin composites. The non-modified resin was used as standard (ST). Material A contained the delivery system providing 4 % (m/m) Irgasan, material B contained 4 % (m/m) methacrylated Irgasan and material C 8 % (m/m) methacrylated Irgasan. Flexural strength (FS), flexural modulus (FM), water sorption (WS), solubility (SL), surface roughness Ra, polymerization shrinkage, contact angle Θ, total surface free energy γS and its apolar γS LW, polar γS AB, Lewis acid γS +and base γS - term as well as bacterial viability were determined. Significance was p < 0.05.ResultsThe materials A to C were not unacceptably influenced by the modifications and achieved the minimum values for FS, WS and SL as requested by EN ISO 4049 and did not differ from ST what was also found for Ra. Only A had lower FM than ST. Θ of A and C was higher and γS AB of A and B was lower than of ST. Materials A to C had higher γS + than ST. The antibacterial effect of materials A to C was significantly increased when compared with ST meaning that significantly less vital cells were found.ConclusionDental resin composites with small quantities of a novel antibacterially doped delivery system or with an antibacterial monomer provided acceptable physical properties and good antibacterial effectiveness. The sorption material being part of the delivery system can be used as a vehicle for any other active agent.
Highlights
Several attempts have been made to modify dental resin composites to avoid or at least to diminish pellicle and bacterial adherence which is considered to be important in early plaque formation [1,2,3,4,5,6,7]
Less vital cells were found for A. viscosus, S. oralis and S. sanguinis on materials A to C (p < 0.0005 to p = 0.031) but for A. naeslundii only on A (p = 0.011) and B (p = 0.003) and for S. mitis only on B and C than on ST
An antibacterial effect of residual monomers was very unlikely because ST and the experimental materials did not differ in the type of the matrix or the filler but only in the addition of the Poly-Irga delivery system or the Methacryl-Irga
Summary
Several attempts have been made to modify dental resin composites to avoid or at least to diminish pellicle and bacterial adherence which is considered to be important in early plaque formation [1,2,3,4,5,6,7]. Germany AMCOL Health & beauty Solutions, Arlington Heights, IL, USA Sigma Aldrich GmbH, Steinheim, Germany university laboratory university laboratory hollow beads (Poly-Pore, Table 1) used as a carrier material, were highly loaded with different types of low surface tension agents resulting in a delivery system which was added in small quantities to experimental resin-based restorative materials. The goal of the present investigation was, based on the new concepts of the aforesaid literature [4,5], to examine the material properties (flexural strength, modulus, water sorption, solubility, surface roughness, polymerization shrinkage, contact angle, surface free energy) of four antibacterially modified experimental dental resin composites and the bacterial viability (A. naeslundii, A. viscosus, S. oralis, S. mitis, S. sanguinis) after 8 or 24 hours, respectively, on these materials. The null hypothesis was that the materials did not differ from ST or among each other (a) in the materials properties and (b) in the total bacterial counts or in the respective bacterium’s viability after 8 or 24 hours observation time
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
