Abstract
Background: Miscarriage is the most common adverse outcome of pregnancy. Bacterial vaginosis (BV) is known as alteration of vaginal milieu. C. trachomatis is intracellular, sexually transmitted bacteria. Objectives: we aimed to investigating the role of BV and C. trachomatis in 1 st trimester miscarriage. Methodology: This study included 95 pregnant women with gestational age < 14 weeks. For each subject we investigate BV by Amsel's criteria and Nugent scoring. Anti chlamydial IgG antibodies were detected using qualitative ELISA. C. trachomatis DNA of cryptic plasmid were detected in urine sample by polymerase chain reaction. Results: BV was not risk factor for 1 st trimester miscarriage, however it was significantly associated with smoking ( P = 0.001), vaginal douching ( P = 0.001), intrauterine device ( P = 0.001) and history of preterm labor ( P = 0.002). C. trachomatis infection was significantly associated with 1 st trimester miscarriage (P = 0.001), hormonal contraception ( P = 0.03) and BV ( P = 0.004). Being older than 30 years was risk factor for miscarriage. Recommendations: We recommend screening of BV and C. trachomatis preconception and in pregnant women for early diagnosis and treatment and to prevent recurrent miscarriage or preter.
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