Abstract
Bacterial toxin–antitoxin (TA) systems are diverse and widespread in the prokaryotic kingdom. They are composed of closely linked genes encoding a stable toxin that can harm the host cell and its cognate labile antitoxin, which protects the host from the toxin's deleterious effect. TA systems are thought to invade bacterial genomes through horizontal gene transfer. Some TA systems might behave as selfish elements and favour their own maintenance at the expense of their host. As a consequence, they may contribute to the maintenance of plasmids or genomic islands, such as super-integrons, by post-segregational killing of the cell that loses these genes and so suffers the stable toxin's destructive effect. The function of the chromosomally encoded TA systems is less clear and still open to debate. This Review discusses current hypotheses regarding the biological roles of these evolutionarily successful small operons. We consider the various selective forces that could drive the maintenance of TA systems in bacterial genomes.
Highlights
Bacteria have long been known to exchange genetic information through horizontal gene transfer, the impact of this dynamic process on genome evolution was fully appreciated only recently using comparative genomics
There is no doubt that bacterial TA systems are evolutionarily successful entities
Their phylogeny is not congruent with the bacterial one [4,46], and their distribution varies greatly between isolates belonging to the same bacterial species ([44,46], Table 2), implying that TA systems are highly mobile
Summary
Bacteria have long been known to exchange genetic information through horizontal gene transfer, the impact of this dynamic process on genome evolution was fully appreciated only recently using comparative genomics (reviewed in [1]). These core genes are interspersed with groups of genes that have been acquired from other prokaryotic genomes by horizontal transmission These genomic islands mostly originate from integration events of mobile genetic elements, such as insertion sequences, transposons, phages, and plasmids. They might, be found in phylogenetically distant species and are not conserved among different isolates belonging to the same bacterial species. Bacterial toxin-antitoxin (TA) systems appear to be subjected to this flux These small gene systems are found in plasmids as well as in chromosomes, and they are thought to be part of the flexible genome [4]. We discuss current hypotheses regarding the biological roles of chromosomally encoded TA systems and consider the various selective forces that could drive the maintenance of TA systems in bacterial genomes
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
