Abstract
As part of an ongoing ICBG (International Cooperative Biodiversity Groups) project we have focused collecting efforts on leaf-cutting ants from different Brazilian biomes aiming the identification of new pharmacologically active natural products from insect bacterial symbionts. The initial collecting efforts have been centered on remaining areas of Atlantic Forest and Cerrado in São Paulo State. Seventy seven bacterial strains were isolated from the bodies and fungal gardens of Acromyrmex ants. All bacterial strains were evaluated in antagonism bioassays against the specific pathogenic fungus Escovopsis sp. Four of them showed good antagonist activity and presents morphology of actinobacteria. The four bioactive strains were cultured using ISP-2 agar and extracted with EtOAc. One extract has been fractionated by chromatographic methods and the antibiotics streptazolin (1) and its E-isomer (2) have been identified by NMR and HRESIMS; in addition to the diketopiperazines Cyclo(Leu-Pro) (3) and Cyclo(Ile-Pro) (4). Compound 1 has also been detected by HPLC-ELSD-PDA in the inhibition zone between the ant symbiont bacteria and Escovopsis sp.
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