Abstract
Bacterial two-component signal transduction systems (TCSs) play a pivotal role in environmental adaptation. In this minireview, two TCSs in Escherichia coli are clarified: the PhoP/PhoQ system, which senses extracellular Mg2+ and controls the expression of the genes for adaptation to environmental Mg2+ deprivation (Mg2+ regulon); and EvgA/EvgS, a signal transduction system that activates expression of the drug efflux pump genes. Furthermore, based on the inhibition of YycF/YycG signal transduction in Bacillus subtilis, a novel strategy for developing a new class of antibacterial agents is described.
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