Bacterial Profile, Antibiotic Susceptibility Pattern and Associated Risk Factors of Urinary Tract Infection Among Patient Suffering from Chronic and/or Acute Prostatitis at the Yaoundé Central Hospital, Centre Cameroon

Abstract

Background: A febrile urinary tract infection in men should suggest acute prostatitis. Any infection of the male urinary tract has the potential to affect the prostate. Acute prostatitis happens when your prostate gland becomes suddenly inflamed. The objectives of our study were to determine the prevalence of urinary tract infections and the associated risk factors in men presenting chronic and/or acute prostatitis. Also, to identify the associated bacterial strains and finally to establish their antibiotic susceptibility profile.
 Materials and Method: We conducted a prospective and cross-sectional study. A total of 77 male participants were recruited, aged 24 years to 84 years at the Urology Department of the Yaounde Central Hospital that presented with clinical signs and symptoms of urinary tract infection from February to June 2021. Urine specimens were collected and analyzed at the Bacteriology laboratory of the Yaoundé University Teaching Hospital. Isolation and identification of bacteria were done using conventional methods. Antibiotic susceptibility testing and interpretation were performed according to CASFM 2021, V.1.0 April. The statistical analysis of our data was done using SPSS version 22.0 software.
 Results: The prevalence of urinary tract infection in our studied population was 15.58% (12/77). Among the 12 participants with urinary tract infection, we isolated and identified six (6) bacteria species; Escherichia coli 25% (3/12), Proteus vulgaris 25% (3/12), Citrobacter freundii 16.67% (2/12), Pseudomonas fluorescent 16.67% (2/12), Enterococcus spp. 8.33% (1/12) and Proteus penneri 8.33% (1/12) respectively. Antibiotic susceptibility testing revealed reduced susceptibility to 3rd generation cephalosporins (cefotaxime, ceftazidime, ceftriaxone). Beta-lactams showed very low activity on almost all the family of Enterobacteriaceae strains isolated. Flouroquinolones (ciprofloxacin, ofloxacin and nalidixic acid) showed a resistance of more than 50% on the majority of the species isolated. All the isolated Gram negative bacteria were multi-drug resistant. Patients with a history of urinary tract tumors, urinary catheters, and diabetes were the most exposed to urinary tract infection; 58.33% (7/12 patients), 50.00 % (6/12) and 41.66% (5/12 patients) respectively. Participants of age >55 years were those presenting the most with urinary tract infection.
 Conclusions: Overall, Enterobacteriaceae were primarily isolated from patients with prostatitis. Urological history such as urinary tract tumors, and Diabetes were significantly associated with UTI.