Abstract
The intracellular pathogen Francisella secretes effector proteins inside host cells; however, their functions have remained unclear. In this issue of Cell Host & Microbe, Ledvina etal. (2018) elucidate the role of one such effector, OpiA, to be a bacterial phosphatidylinositol-3-kinase that alters phagosomal trafficking and can promote intracellular bacterial replication.
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