Abstract
Tumor-associated macrophage (TAM) plays an important role in tumor immune regulation. Reprogramming TAMs to reshape immunosuppressive tumor microenvironment (TME) is a promising antitumor strategy. Herein, imiquimod (R837) and black phosphorus quantum dots (BPQDs) are encapsulated in bacterial outer membrane vesicles (OMVs)-clothed liposomes to obtain RB@OL nanoparticles, which are further delivered by M1-type macrophages through phagocytic loading (RB-OL@M). Owing to the natural homing ability of macrophages to tumor sites, RB-OL@M actively targets cancerous region after intravenous injection. Meanwhile, upon laser irradiation, RB@OL is released from macrophages to exert combinational photoimmunotherapy due to the excellent phototherapeutic property of BPQDs and TAM regulating potential of R837. Benefiting from this versatile strategy, RB-OL@M effectively delays the growth of 4 T1 breast tumors and prevents the occurrence of their dreadful lung metastasis, largely prolonging the survival of 4 T1 tumor-bearing mice. Overall, this work offers a promising antitumor approach based on live cell-mediated multirole nanoplatform.
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