Abstract
AbstractMetalloproteases, in which zinc metal ion is essential for catalytic activity, are produced by various human pathogenic bacteria. These metalloproteases have the consensus sequence HEXXH, in which two histidine residues function as the first and second zinc ligands. However, on the basis of the location of the third zinc ligand, they are classified into three families: the thermolysin, serralysin and neurotoxin families. Members of the thermolysin family are synthesized as an inactive precursor with a N-terminal propeptide, and maturation of the precursor is achieved by several processing stages. The metalloprotease in the serralysin family is generated without a conventional propeptide, and its transport is supported by additional secreted proteins.A wide variety of pathological actions of bacterial metalloproteases have been documented. In local bacterial infections, such as keratitis, dermatitis and pneumonia, the metalloprotease functions as a decisive virulence determinant. The protease gener...
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