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Abstract
We found that retinoic acid-inducible gene-I (RIG-I) is induced in cultures of vascular endothelial cells stimulated with bacterial lipopolysaccharide (LPS). RIG-I encodes a protein belonging to the DExH box family that has diverse roles in the regulation of gene expression and cellular functions. Overexpression of RIG-I resulted in upregulation of cyclooxygenase-2 (COX-2) expression. RIG-I may have important roles in vascular pathology through its activity in regulating the COX-2 gene.
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