Abstract
Temporal shifts have been known to occur in antibiotic sensitivity patterns of organisms causing cholangitis.The aim of this prospective study conducted on 100 patients of extra hepatic biliary obstruction (EHBO) was to identify the common microorganisms cultured from bile obtained during Endoscopic retrograde cholangiography and to study their local sensitivity pattern.Sixty six patients had growth in bile culture,the maximum growths amongst all micro-organisms were of Escherichia coli (40.9%) and Pseudomonas aeruginosa (40.9%). Growth rates were significantly higher in patients with non- malignant causes of biliary obstruction than those with malignant causes. Polymixins had the highest sensitivity to cultured bacteria followed by aminoglycosides and Imipenem.Study of culture & sensitivity pattern helps in deciding empirical antibiotic therapy in patients with cholangitis and it should be based on local sensitivity patterns
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