BACTERIAL INFECTION MODEL AND ANTIBIOTIC RESISTANCE AT THE NEW PRIVATE HOSPITAL

Abstract

Objectives: Survey of bacterial pathogens and antibiotic resistance at Tam Anh Hospital in 2021.Material and methods: Retrospective method. Bacteria were isolated from specimens at the Department Microbiology of Laboratory center at Tam Anh Hospital in 2021 which were identified and tested drug susceptibility by Vitek 2. By CLSI standards.Results: Distribution of pathogenic strains: In 2021, 880 strains of bacteria were isolated, 8 types of most common bacteria were Escherichia coli (46%), Staphylococcus aureus (16.8%), Klebsiella pneumoniae (14.3%), Staphylococcus haemolyticus (6%), Pseudomonas aeruginosa (4.3%), Enterococcus faecalis (3.9%), Enterobacter cloacae (2.9%), Acinetobacter baumannii (2.3%). Antibiotic resistance: Escherichia coli was resistant to most second and third generation cephalosporins, trimethoprim/sulfamethoxazole, fluoroquinolone, still sensitive to carbapenems, piperacillin/tazobactam, amikacin, tigecylin, cefepime, ceftazidim, gentamycin, tobramycin, nutrofurantoin. The ESBL rate was 36%. Staphylococcus aureus was resistant > 30% to bezilpenicillin, erythromycin, clindamycin, oxacillin, tetracycline, still sensitive to levofloxacin; rifamycin, Vancomycin; fusidic acid; nitrofurantoin; linezolid; teicoplanin; tigecycline. The MRSA rate is 59.6%. Klebsiella pneumoniae was resistant > 30% to cephalosporin, fluoroquinolone, ampicillin/sulbactam, piperacillin/tazobactam, nitrofurantoin,moxifloxacin. For meropenem were resistant 18%, ertapenem 19%. The ESBL rate was 19%. Staphylococcus heamolyticus was resistant > 30% to fluoroquinolone, bezilpenicillin, erythromycin, fusidic acid, oxacillin, trimethoprim/sulfamethoxazole. Tetracycline, still sensitive to moxifloxacin, rifamycin, nitrofurantoin, gentamicin, linezolid, teicoplanin, tigecycline, vancomycin.Pseudomonas aeruginosa was resistance > 30% to cephalosporin, aminoglycoside, fluoroquinolone, tigecylin, cefepime, was resistance > 20% to meropenem, ceftazidime, imipenem, piperacillin/tazobactam, especially not resistance to colistin. acinetobacter baumannii was resistance > 50% to cephalosporin, aminoglycoside, carbapenem, piperacillin/tazobactam, ticarcillin/clavuclanic acid, trimethoprim/sulfamethoxazole still sensitive to colistin, tigecycline; tobramycin.Conclusion: The common bacteria in at Tam Anh Ho Chi Minh Hospital in 2021 were Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Staphylococcus haemolyticus, Pseudomonas aeruginosa, Enterococcus faecalis, Enterobacter cloacae, Acinetobacter baumannii. In the current situation of multidrug resistant bacteria, understanding the distribution of sepsis parthogens and updating their antibiotic resistance will be a great help to clinicians in the antibiotic selection to treat as well as contribute to reduce antibiotic resistance,