Abstract
✓ Twenty-five patients with acute head trauma were studied prospectively for appearance of infection during hospitalization in an acute care unit. The study demonstrates: multiple changes in bacterial flora particularly in the respiratory tract, a significant morbidity due to bacterial changes in the respiratory tree, a negligible incidence of bacterial disease due to physiological monitoring procedures, and an inability to correlate changing flora with specific therapeutic or manipulative procedures except tracheostomy. Mortality correlates well with the severity of illness and indirectly with changes in bacterial flora. Despite the frequent isolation of coagulase-positive staphylococci, severity of infectious complications correlate most closely with the acquisition of gram-negative organisms in the respiratory tract.
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