Abstract
The case of a forty-one-year old white woman with fatal Salmonella endocarditis is presented. The occurrence of Salmonella endocarditis is rare with only twenty-eight cases reported from 1936 through 1959. In the majority of cases there was some form of pre-existing valvular disease. The results of therapy remain unsatisfactory with only two known survivors. One of the difficulties of therapy is illustrated by the present case report. After therapy was instituted blood cultures were consistently negative. In vitro studies revealed the organism to be sensitive to several therapeutic agents. Despite this, Salmonella typhimurium was readily cultured from the left atrial thrombus at autopsy. Inability of the therapeutic agent to reach the organism appears to be the major difficulty.
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