Bacteria mediated cancer treatment (BMCT) and quorum sensing system in BMCT

Abstract

Many treatments against cancer already exist. For example, radiation therapy, chemical therapy and immunotherapy, combined the physical surgery, these treatments do make a remarkable effect in inhibiting the growth of the tumor and thus prolonging the patients life. However, most of the treatments mentioned above would simultaneously damage normal cells and cause trauma or pain to the patients. In recent years, researchers have turned their attention to the remarkable natural abilities of certain bacteria such as Salmonella and E. coli, in suppressing malignant cells and solid tumors. Bacteria-mediated cancer treatment (BMCT) has emerged as a promising approach that offers the potential for reduced patient trauma and enhanced precision in targeting cancerous tissues. Furthermore, the integration of quorum sensing systems, initially utilized in the fermentation process holds promise in augmenting the navigational capabilities of bacteria. This advance opens the door to the development of highly location-sensitive bio-agents capable of delivering substantial quantities of specific therapeutic proteins directly to tumor sites. This review aims to comprehensively examine existing BMCT methodologies and explore the quorum sensing pathways that have been identified. Additionally, it contemplates the feasibility of synergizing these two systems to offer a novel perspective on cancer treatment.