Abstract
Although key coagulation factor activities are maintained in thawed cryoprecipitate stored for up to 24h at ambient temperature, several jurisdictions limit such storage to 4-6h. Here, we separately spiked thawed cryoprecipitate units with four bacterial strains: Staphylococcus epidermidis, Serratia liquefaciens, Pseudomonas putida and Pseudomonas aeruginosa. No strains grew in the first 4h of storage, but by 24h, three of four exhibited up to 1000-fold proliferation. Pathogen inactivation technologies could be explored to mitigate the safety risk posed by extending storage of thawed cryoprecipitate at room temperature.
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