Abstract
In this issue of Cell Chemical Biology, Chen etal. (2017) report that 4-hydroxyestrone and pyridinestroneacid are intermediates in the 4,5-seco pathway of aerobic estrogen degradation by the bacteriumSphingomonas. The authors identify a gene for 4-hydroxyestrone 4,5-dioxygenase and find it tobe widely distributed in diverse proteobacteria, suggesting that this pathway is environmentally significant.
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