Bacteremia during neutropenia is a predictive factor for invasive fungal infection in children

Abstract

Invasive fungal infection (IFI) is a critical complication in the management of hematologic and malignant disease. Given that there is a tendency for IFI to occur after bacteremia following febrile episodes during neutropenia, the aim of this study was to determine if bacteremia was a predictive factor for IFI in pediatric patients with hematologic and malignant disease. Sixty-two patients (32 boys, 30 girls; median age, 4 years) with hematologic or malignant disease who had received chemotherapy, immunosuppressive therapy, and/or hematopoietic stem cell transplantation, and experienced febrile episodes during neutropenia were enrolled. In patient-based analysis, clinical features of 62 patients were compared between those with and without IFI. Meanwhile, in febrile episode-based analysis, clinical features were analyzed for 268 febrile episodes occurring during neutropenia in the 62 patients. Patient-based analysis showed that relapse of original disease and acute myeloid leukemia were risk factors for IFI. Meanwhile, febrile episode-based analysis identified bacteremia following febrile episodes during neutropenia as a potential risk factor for IFI. This is the first report to identify bacteremia following febrile episodes during neutropenia as a predictive factor for IFI in pediatric patients with hematologic or malignant disease. When bacteremia is detected in such patients, sufficient preventive measures against IFI, including intensive use of antifungal agents, are warranted.