Baclofen Does Not Modify the Gastric and Colonic Transits in Mice while It Inhibits Contractions of the Isolated Guinea Pig Ileum

Abstract

Baclofen inhibits the transient lower esophag‐eal sphincter relaxations and thus it could be a potential treatment for the gastroesophageal reflux disease. The present work was conducted to study effects of baclofen on the gastrointestinal motility in experimental animals in three sets of experiments. In the first and second sets, 32 mice randomly divided into four groups (n=8) were used to evaluate effects of baclofen (4.0 mg/kg intraperitoneally) on the gastric transit (assessed by the charcoal meal test) and the colonic transit (assessed by the colonic bead expulsion time). In the third set, 16 guinea pigs randomly divided into two groups (n=8) were used to assess effects of baclofen (10 mM) on the electrically‐induced contractions of the isolated guinea pig ileum. Baclofen produced non‐‐significant changes in the gastric and colonic transits while it significantly inhibited the electrically‐induced contractions of the isolated guinea pig ileum. It is concluded that baclofen has favorable effects on the gastrointestinal motility supporting its potential value in treatment for the gastroesophageal reflux disease.Support or Funding InformationNoneThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.