Abstract
Background: Multi-stage surgical treatment of patients with complicated urgent abdominal pathology is used in the most severe clinical situations. We have performed and published a systematic review (SR) and meta-analysis (MA) comparing vacuum-assisted laparostomy (VAC-LS) and other options for multi-stage surgical treatment. However, the results of randomized clinical trials (RCTs) and MA are often impossible to reproduce in real world-data (RWD). The aim: Evaluate the prerequisites for using the results of SR, MA in the RWD. Materials and methods: Based on the results of our secondary research study from 11 135 screened publications from 2007 to 2022, of which 33 are included in SR and 12 in MA. The results of MA and the data of the RWD of the hospital surgery clinic of the Volg State Medical University were compared. Results: VAC-LS has some advantages over other treatments, setting the stage for use in RWD. Conclusions: The results of the SR and MA performed by us have reasonable prerequisites for use in the RWD.
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