Background impulse activity of neurons of the fastigial cerebellar nucleus of intact and labyrinthectomized rats under conditions of vibration

Abstract

In acute experiments on nembutal-anesthetized (40 mg/kg, i.p.) albino rats, we recorded extracellularly and analyzed the background impulse activity (BIA) of neurons of the fastigial nucleus of the cerebellum. Experiments were carried out on intact and labyrinthectomized rats in the norm and after long-lasting (up to 15 days) influence of general vertical vibration (60 Hz, 0.4 mm, 2-h-long everyday sessions). Distributions of the neurons according to the level of regularity of BIA, dynamics of spike trains, pattern of histograms of interspike intervals (ISIs), and different frequency ranges of BIA were plotted; the mean frequency of this activity and the coefficient of variation of ISIs were also calculated. Possible mechanisms of the effects of long-lasting vibration of different durations on the BIA generated by neurons of the fastigial cerebellar nucleus in intact animals and after switching off of labyrinth afferent inputs are discussed.