Abstract
Synthesis of cationic, chiral PNA analogues with an extra atom in the backbone ( bepPNA) is reported. The (2 S,4 S) geometry of the pyrrolidine ring, and an additional carbon atom in the backbone of homopyrimidine- bepPNAs resulted in the optimization of the inter-nucleobase distance, such that selective binding to complementary RNA over DNA was observed in the triplex mode. It was evident from circular dichroism studies that oligomers with mixed aminoethylglycyl–bep ( aeg– bep) repeating units, and also bepPNA with homogeneous backbone attained structures quite different from those of aegPNA 2:RNA/DNA complexes. The bepPNA, when incorporated in a duplex forming mixed purine–pyrimidine sequence, also showed a preference for binding complementary RNA over DNA.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
