Abstract
A fluorescein-based imaging probe turns-on upon binding to the human γ-aminobutyric acid type A (GABAA) receptor. In their Research Article (DOI: 10.1002/anie.202205198), Pedro A. Sánchez-Murcia, Leticia González et al. use multiscale calculations to show that the fluorescence is due to the rod-like conformation of the probe within the receptor. By contrast, the probe folds in solution and intramolecular ππ-stacking interactions quench the emission.
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