Back Cover: Targeted Protein Upregulation of STING for Boosting the Efficacy of Immunotherapy (Angew. Chem. Int. Ed. 18/2023)

Abstract

Targeted protein upregulation by modulating the interaction between a target protein and its E3 ligase is the opposite strategy of targeted protein degradation (PROTAC). In their Research Article (e202300978), Dong-Sup Lee, Seung Bum Park enhanced the cellular STING levels by inhibiting STING-TRIM29 interaction, which activates innate immune responses in the tumor microenvironment and potentiates the immune-oncology treatment by changing COLD to HOT tumor. Thus, targeted protein upregulation can be an alternative drug discovery strategy for undruggable targets.