Abstract
European Journal of ImmunologyVolume 51, Issue 5 Back CoverFree Access Back cover story: Eur. J. Immunol. 5'21 First published: 05 May 2021 https://doi.org/10.1002/eji.202170058AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Abstract Our back cover features H&E stainings from the lungs of LPS-induced sepsis mice pretreated with Nitrosonisoldipine (NTS), a photodegradation product of nisoldipine. The mice displayed the alleviated lung injury. The image is taken from Chen et al. (pp. 1234–1245), where the authors show that pretreatment with NTS confers protection against sepsis in mice. NTS blocks both the non-canonical and canonical pyroptotic pathways but does not affect apoptosis. Mechanistically, as a selective caspase inhibitor, NTS could directly and irreversibly inhibit the enzyme activities of inflammatory caspases (i.e. caspase-1/-4/-11). Furthermore, NTS is safe for intraperitoneally injection in mice, suggesting that it may be used as a prototype to develop drugs for sepsis treatments. Volume51, Issue5May 2021 RelatedInformation
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