Abstract
European Journal of ImmunologyVolume 46, Issue 12 Back CoverFree Access Back Cover Story: Eur. J. Immunol. 12'16 First published: 05 December 2016 https://doi.org/10.1002/eji.201670128AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Our back cover features an H&E stained biopsy section from a patient with eosinophilic myocarditis. Countless heart-infiltrating eosinophils with bright pink granules and bi-lobed nuclei are visible between large, striated cardiomyocytes. In addition, T cells and macrophages are infiltrating the heart. This image relates to the article by Diny et al. (pp. 2749–2760), in which the authors analyze the pathway required for eosinophil trafficking to the heart by examining heart biopsies from myocarditis patients and a murine myocarditis model. IL-4 and IL-13 induce production of eotaxins CCL11 and CCL24 by cardiac fibroblasts and macrophages. In response to eotaxins, eosinophils migrate to the heart via the receptor CCR3. Volume46, Issue12December 2016 RelatedInformation
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