Abstract
DOI: 10.1002/sscp.202000118 The cover picture shows, Trigonelline (Tr) a quaternary base alkaloid, which acts by affecting β-cell regeneration and insulin secretion. Tr lowers the blood glucose and lipid levels due to which it is used in the treatment of co-morbid diseases. Herein, we have aimed to develop a bioanalytical method for estimation of Tr using UPLC-MS/MS and explore the pharmacokinetic profile. The anti-diabetic, antilipidemic efficacy studies were also conducted in the high-fat diet-induced streptozotocin-diabetic rat. The experimental results suggest that Tr follow the two compartmental pharmacokinetic model. In addition, Tr exhibited a significant anti-hyperglycemic and antihyperlipidemic efficacy in high-fat diet-induced streptozotocin induced diabetic rats.
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