Back Cover: Phosphine-Catalyzed Remote β-CH Functionalization of Amines Triggered by Trifluoromethylation of Alkenes: One-Pot Synthesis of Bistrifluoromethylated Enamides and Oxazoles (Angew. Chem. Int. Ed. 13/2015)

Abstract

A CF3 radical could be generated from Togni's reagent in a single-electron-transfer process catalyzed by a simple phosphine. In their Communication on page 4041 ff., B. Tan, X.-Y. Liu, and co-workers utilize this chemistry to realize the first phosphine-catalyzed radical tandem route that enables the concomitant functionalization of an alkene and the remote β-CH bond of amine derivatives to give bistrifluoromethylated enamides and trisubstituted 5-(trifluoromethyl)oxazoles, respectively.