Abstract
Sugar nucleotides are essential glycosylation donors in carbohydrate metabolism. In their Research Article (e202115696), Liuqing Wen and co-workers developed a general strategy for the efficient preparation of rare sugar nucleotides. Complex de novo biosynthesis of rare sugar nucleotides was recognized as cascade reactions. The cascade reactions were driven toward the formation of the target sugar nucleotides through a cofactor regeneration system (CRS), thus resulting in clean conversion.
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