Back Cover: Aromatic‐Turmerone Attenuates LPS‐Induced Neuroinflammation and Consequent Memory Impairment by Targeting TLR4‐Dependent Signaling Pathway

Abstract

Mol. Nutr. Food Res. 2018, 62, 1700281 DOI: 10.1002/mnfr.201700281 Oral administration of aromatic-turmerone could reverse lipopolysaccharide (LPS)-induced memory disturbance and normalize glucose intake and metabolism in the brains of mice. Moreover, aromatic-turmerone significantly limits brain damage by inhibiting the activation of microglia and the generation of inflammatory cytokines. Further in vitro study reveals that aromatic-turmerone-targeted Toll-like receptor 4 (TLR4) mediates downstream signaling and lowers the release of inflammatory mediators.