Abstract
Since its foundation in 1971, Bachem has grown sustainably over the last 50 years and is excellently positioned as the leading company for the development and production of TIDES i.e. peptides and oligonucleotides. Bachem's success relies on its commitment to manufacturing high-quality active pharmaceutical ingredients (APIs) alongside its continual passion for innovative chemistry and technologies. This review aims at summarizing improvements in high-quality peptide manufacturing as well as recent advances towards sustainable and innovative technology in peptide chemistry, thereby reducing the environmental footprint.
Highlights
The therapeutic asset of peptide-based active pharmaceutical ingredients (APIs) has significantly grown over the preceding decades and today about 80 peptide drugs are already marketed ensuring a bright future for peptide therapeutics.[1]
This review aims at summarizing improvements in high-quality peptide manufacturing as well as recent advances towards sustainable and innovative technology in peptide chemistry, thereby reducing the environmental footprint
The synthesis and purification technologies are an area for which innovation and development of sustainable and robust processes in the production of peptide APIs is sought after.[4] For the last five decades, Bachem has been a highly reliable provider of high-quality peptide APIs manufactured under cGMP standards and a trusted partner for numerous biopharmaceutical companies in their peptide drug development programs.[5]
Summary
The therapeutic asset of peptide-based APIs has significantly grown over the preceding decades and today about 80 peptide drugs are already marketed ensuring a bright future for peptide therapeutics.[1]. At Bachem we are continuously striving to improve our state-of-the-art synthetic and purification platform as well as to invest resources into scouting new technologies and effectively implementing them to minimize environmental impact of largescale API production In this context, Bachem has systematically developed a strategy to identify and evaluate environmentally friendly solvent alternatives for solid-phase peptide synthesis (SPPS).
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