Abstract
Baccharis crispa attenuates toxic hepatitis induced by acetaminophen and carbon tetrachloride in mice
Highlights
There is little doubt about the health value of traditional medicine around the world
Considering the serum level of GPT, GOT, and alkaline phosphatase (ALP) of mice treated with different doses of crude extract of B. crispa (CEBc), a clear liver protective effect was denoted
The elevation of serum level of GOT induced by APAP was significantly attenuated in mice orally pretreated, respectively, with CEBc (50.0, 200.6 ± 35.6; 100.0, 145 ± 66.2; 200.0, 112 ± 58; and 300.0, 222.8 ± 26.0, mg/kg and U/L) and silymarin (204.2 ± 76.2 U/L)
Summary
There is little doubt about the health value of traditional medicine around the world. According to the World Health Organization (World Health Organization, 2013), herbal medicine, traditional treatments, and traditional practitioners are the main source of healthcare and sometimes the only source of care. In Paraguay, herbal medicine is culturally accepted, accessible, in proximity or cultivated into home garden, affordable, and trusted by the population. Unfocalized efforts from either health policymakers, academicians, or researchers contribute poorly to the availability of traditional medicine of proven quality, safety, and efficacy. Many herbs have been used in clinical practice for centuries as natural remedies, either for preventing or for the treatments of liver diseases in both western and eastern populations. Among the many hepatoprotective herbs/compounds, Silybum marianum (milk thistle), glycyrrhizin, Bupleurum chinense, Schisandra chinensis, and Phyllanthus amarus have been most widely studied and documented (Wang et al, 2007)
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