Abstract

Babesia bovis is an economically important, obligate intracellular protozoan that causes the most pathogenic form of bovine babesiosis. It occurs in Asia, Africa, Australia, and in Central, South, and southern North America, and parts of southern Europe. Rhipicephalus microplus is its most important vector. Infected female ticks produce infected offspring (transovarial transmission), which are the main source of transmission to cattle. Its life cycle contains an asexual replication in cattle erythrocytes, a sexual replication in the tick midgut, and an asexual replication in tick salivary glands. Younger animals have increased resistance compared with adults. This spleen-dependent resistance is attributed to a strong innate immunity. Prevention relies on the use of acaricides and live attenuated vaccines, available in some endemic countries. Vaccinated animals or those recovered from infection develop adaptive immunity, but they remain infected and may serve as reservoirs for transmission.

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