Abstract
Immunological analysis of serum from calves infected with Babesia argentina revealed two substances absent from serum of noninfected calves. The first of these was immunologically identical with bovine fibrinogen and its presence in serum was probably the result of intravascular coagulation and subsequent fibrinolysis. The second substance appeared to be a pigmented macromolecular complex containing a number of proteins found in the tissues of normal cattle. It was also found in serum of a calf with chemically induced hemolytic anemia and thus was unlikely to contain material derived from the parasites. The possibility that it might stimulate antibodies in the host capable of participating in the removal of damaged erythrocytes from the circulation is discussed.
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