B7-H1和Bcl-2在上皮性卵巢癌中表达及其临床意义

Abstract

Objective To investigate the expressions of B7-H1 and Bcl-2 proteins in epithelial ovarian cancer, and to explore the association of the expressions of B7-H1 and Bcl-2 with clinicopathological features. Methods The expressions of B7-H1 and Bcl-2 proteins were detected by immunohistochemistry in 80 cases of epithelial ovarian cancer tissues and 20 normal ovary tissues. The association of the expressions of B7-H1 and Bcl-2 with the clinicopathological features was analyzed. Results The positive expression rates of B7-H1 and Bcl-2 in epithelial ovarian cancer tissues were 77.5% (62/80) and 58.8% (47/80), both higher than 15.0% (3/20) and 10.0% (2/20) in normal ovary tissues with significant difference (χ2=27.473, P<0.05; χ2=15.216, P<0.05). Both of Bcl-2 and B7-H1 expressions in epithelial ovarian cancer tissues were negatively correlated with the differentiation degree of epithelial ovarian cancer (χ2=9.367, P<0.01; χ2=11.702, P<0.01). The Bcl-2 expression in epithelial ovarian cancer tissues was positively correlated with the FIGO stage (χ2=7.766, P<0.01). The expression of B7-H1 was positively correlated with the expression of Bcl-2 in epithelial ovarian cancer (r=0.400, P<0.01). Conclusion The expressions of B7-H1 and Bcl-2 are up-regulated in epithelial ovarian cancer and they correlate to each other positively. The expressions of B7-H1 and Bcl-2 are correlated with the invasion and metastasis of epithelial ovarian cancer. The detection of B7-H1 combined with Bcl-2 may have an important clinical significance in the diagnosis and treatment for patients with epithelial ovarian cancer. Key words: Ovarian neoplasms; Gene; B7-H1; Bcl-2; Immunohistochemistry