Abstract
A technique for single-shot, localized, water-suppressedin vivo1H NMR with high immunity toB1inhomogeneities is described. The single-shot localization is based on complete outer-volume suppression which is achieved with optimized, adiabatic BIR-4 pulses in combination withB0gradient modulation.B1-insensitive water suppression is achieved with BISTRO, a train of selective adiabatic full-passage pulses interleaved withB0gradient crushers. Computer simulations based on the Bloch equations, experimental images of the localized volume, andin vivo1H spectroscopy experiments demonstrate the excellent spatial localization and water suppression.
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