B-005 Blood pH and Phosphate Tend to Follow an Inversely Correlated Homeostatic Status

Abstract

Abstract Background Phosphorus containing biomolecules perform an essential biochemical function in maintaining extra and intracellular acid-base status. Maintaining normal concentration (2.5–4.5 mg/dl) of phosphorus is indispensable for optimal cellular function and homeostasis. Serum concentration of phosphorus (mainly inorganic orthophosphates) is an indicator of H2PO4−/HPO42− acid-base buffer condition. Disturbance of pH could be an immediate impact of many respiratory and metabolic morbidities. Extra/intracellular redistribution of phosphates in response to an abnormal pH is an established homeostatic phenomenon. Failure to maintain an appropriate phosphate level to support the extra/intracellular redistribution may result in a pH shock. Therefore, it is important to have a clear understanding on how blood phosphate and pH levels are interconnected which could assist in guiding therapeutic interventions to fix phosphate abnormalities and acid-base disturbances. This study examined the homeostatic correlation between blood pH and phosphate level among hospitalized and ambulatory patients. Methods Serum phosphorus concentration and pH were retrieved from the biochemical profiles and arterial blood gas data of hospitalized and ambulatory patients who presented or admitted our tertiary care level university hospital during the first week of July, 2021. Logarithmic (base ten) values of phosphorus concentration were determined to normalize the distribution of the phosphorus data more uniform. Correlation analyses between phosphorus/log[phosphorus] and pH were performed by GraphPad PRISM version 8. Results A total of 101 corresponding blood gases and phosphate levels were obtained. Both phosphorus and log [phosphorus] values of the patients displayed an inverse correlation with arterial pH (Figure 1a and b). Pearson r values demonstrated a negative correlation between phosphorus/log [phosphorus] and pH (−0.6737 and −0.6450, respectively).Fig. 1. Conclusion Monitoring of phosphate levels provide an early indication of acid base status. Phosphorus level maintains an inverse correlation with pH profile. Therefore, a therapeutic manipulation of phosphorus or pH may have a mutual effect requiring further investigation.