Abstract
The aim of this study was to evaluate the plasma level changes of B-type natriuretic peptide (BNP), biochemical marker of heart failure, and echocardiographic parameters during mitoxantrone treatment in 22 multiple sclerosis (MS) patients (8 males, 14 females, mean age 37.1 ± 6.6). Mitoxantrone (after mean cumulative dose of 58.0 ± 7.0 mg/m 2) did not alter left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), posterior wall thickness (PWT) and left ventricular end-diastolic volume (LVEDV). However, mean plasma level of BNP raised from 14.53 ± 3.29 pg/ml at the baseline to 16.79 ± 3.05 pg/ml and 18.83 ± 4.90 pg/ml ( P < 0.01) after mean mitoxantrone dose of 30.7 ± 5.9 mg/m 2 and 58.0 ± 7.0 mg/m 2, respectively. These results strongly suggest subclinical myocardial dysfunction in mitoxantrone-treated group. We assume, that low-cost, repeated BNP measurements may be a good alternative for detection of early subtle myocardial injury in MS patients during routine mitoxantrone therapy.
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