B-PO05-200 EJECTION FRACTION IMPROVEMENT DOES NOT REFLECT CHANGES IN HEALTH-RELATED QUALITY OF LIFE FOLLOWING CARDIAC RESYNCHRONIZATION THERAPY

Abstract

Cardiac resynchronization therapy (CRT) can improve left ventricular ejection fraction (EF) and health-related quality of life (HRQoL) in patients with heart failure with reduced EF (HFrEF). It is unknown if improvements in HRQoL reflect EF response to CRT. To determine if EF response after CRT correlates with improved HRQoL. We included HFrEF patients who underwent CRT and had EF and HRQoL data available at baseline and within one year. EF response was categorized as absent (0% change or decrease), modest (0-19% increase), or significant (>20% increase). HRQoL response was categorized as improved (by >5 points), unchanged (<5 points), or worsened (by >5 points). We examined the associations between EF response and generic (PROMIS tools) and HF-specific (KCCQ-12) HRQoL. The group included 84 patients with mean age of 66 years and baseline EF of 32%; 44% were female (n=37). Nineteen percent (n=16) had significant EF response and 60% (n=50) had a modest response. AF burden (p=0.2) and mitral regurgitation severity (p=0.1) were similar across EF groups. General Health score was significantly associated with EF response (Figure, p=0.036). However, PROMIS Physical Function (p=0.5), PROMIS Depression (p=0.8), and KCCQ-12 (p=1.0) were not. A significant proportion of patients without EF improvement had improved HRQoL scores after CRT implant. In this cohort, CRT was associated with a modest to significant EF response in the majority. However, EF response did not strongly correlate with generic or HF-specific HRQoL tools. These results warrant further investigation into the determinants of improved HRQoL in HFrEF.