B. Pietrosimone, CHEMOKINE ENA-78/CXCL5 IS PRODUCED BY OA SYNOVIAL FIBROBLASTS IN RESPONSE TO A MATRIX DAMAGE STIMULUS AND IS FOUND IN SYNOVIAL FLUID COLLECTED FROM PATIENTS AFTER ACL INJURY

Abstract

Purpose: Cartilage degradation in OA is due to the overproduction of secreted proteases by chondrocytes, including the matrix metalloproteinases (MMPs). Synoviocytes can also contribute to this activity by releasing mediators that exacerbate joint destruction. Cross-talk between synovial cells and chondrocytes mediated by proinflammatory factors could intensify catabolic signaling activity in both cell populations to contribute to joint tissue destruction. Protease cleavage of matrix proteins generates matrix fragments that include fibronectin fragments (FN-f) found in OA cartilage and synovial fluid.