Abstract
A unique C-type virus, B-MuX, was isolated from nonproducer, BALB/c-transformed fibroblasts after IdUrd induction. B-MuX has the envelope gp70 properties of the endogenous BALB:virus-2 genome as determined by neutralization, interference, host-range characteristics and competition radioimmunoassays. Tryptic peptide analysis of gp70 from B-MuX revealed that B-MuX gp70 contains peptides in common to xenotropic virus gp70s and overall was very similar in structure to the xenotropic BALB: virus-2 gp70. In contrast, the gag gene products are serologically identical with the p15 and p12 of the endogenous, ecotropic virus. The p30 of B-MuX is structurally similar to that of the endogenous, ecotropic virus, and differs from the p30 of BALB/c xenotropic viruses as determined by tryptic peptide analysis. The results suggest that either B-MuX is a new type of endogenous, xenotropic virus or a recombinant between the endogenous xenotropic and ecotropic viruses. The unaltered xenotropic behavior of B-MuX demonstrates that the gag gene region does not contribute to this virological property.
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