Abstract
Osteoarthritis (OA) has been historically categorized as a noninflammatory arthritis, driven by mechanical wear and tear and characterized by progressive deterioration of joint structure (e.g. cartilage degeneration, subchondral bone sclerosis, osteophytosis). However, inflammation is being increasingly recognized as a contributor to joint structural damage and symptoms in OA. Specifically, synovial inflammation is associated with radiographic OA incidence, progression, and pain severity. 1 Felson D.T. Niu J. Neogi T. Goggins J. Nevitt M.C. Roemer F. et al. Synovitis and the risk of knee osteoarthritis: the MOST Study. Osteoarthritis Cartilage. 2016; 24: 458-464 Abstract Full Text Full Text PDF PubMed Scopus (139) Google Scholar , 2 Perry T.A. Parkes M.J. Hodgson R.J. Felson D.T. Arden N.K. O’Neill T.W. Association between bone marrow lesions & synovitis and symptoms in symptomatic knee osteoarthritis. Osteoarthritis Cartilage. 2020; 28: 316-323 Abstract Full Text Full Text PDF PubMed Scopus (27) Google Scholar , 3 Roemer F.W. Guermazi A. Felson D.T. Niu J. Nevitt M.C. Crema M.D. et al. Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST Study. Ann Rheum Dis. 2011; 70: 1804-1809 Crossref PubMed Scopus (258) Google Scholar
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