Abstract
Immunosenescence is considered a major contributory factor to the increased frequency of morbidity and mortality among elderly. Immunosenescence studies focus mainly on T cells, although B cells are affected too. In our studies we analyzed B cells in two classes of individuals: old people (O), (age range 70‐85 years) and centenarian offspring (CA). Our data showed difference in number of B cells from O and CA. B cells were analyzed according to the expression of sIgD and CD27. B cells were classified as follows: IgD+CD27−(naïve),IgD+CD27+(unswitched‐memory),IgD−CD27+ (switched ‐memory) and IgD−CD27−(double negative, DN). As expected, in both cohorts we observed a marked decreased of B cell count although within the B cell population, CA do not behave as O subjects. Indeed, in CA , naïve B cells are more abundant whereas DN B cells don't show the typical increase that we have previously demonstrated in healthy elderly donors. So, B cells of the CA seem to be more similar to that of young respect to the old one. B cell subsets changes could represent a hallmark of immunosenescence and could be used as a biomarker of human life span, potentially useful for the evaluation of anti‐ageing treatment.This work was supported by grants from the Italian Ministry of Education, University and Research (MIUR, ex 40%)
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