Abstract
Both the nature of germinal centres and the origin of Burkitt lymphoma have given rise to an exceptional level of divergent speculation. The histological similarities between this tumor and germinal centres was recognised as long ago as 1961 by O’Conor. Mann et al (1976) noted that several American patients with Burkitt lymphoma had tumors which appeared to arise in germinal centres in lymph nodes or Peyer’s patches. In a careful review of the histopathological evidence for this relationship Lennert (1978) concluded that on morphological grounds the Burkitt lymphoma cell most closely resembled an intermediate between a true centroblast and a B blast cell. This paper reports the findings of a study of synchronised germinal centre formation in rats. It shows that germinal centre formation is most apparent in primary B cell responses; secondary responses being associated with massive extrafollicular B cell responses. Finally the phenotype of germinal centre cells is compared with that of cells derived from Burkitt lymphoma. It is concluded that there is an extraordinary concordance between the cells found in normal germinal centres and the neoplastic cells of Burkitt lymphoma.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
