B Cell Intrinsic Mechanisms Constraining IgE Memory.

Brice Laffleur,Michel Cogné,Zeinab Dalloul,Orianne Debeaupuis

doi:10.3389/fimmu.2017.01277

Abstract

Memory B cells and long-lived plasma cells are key elements of adaptive humoral immunity. Regardless of the immunoglobulin class produced, these cells can ensure long-lasting protection but also long-lasting immunopathology, thus requiring tight regulation of their generation and survival. Among all antibody classes, this is especially true for IgE, which stands as the most potent, and can trigger dramatic inflammatory reactions even when present in minute amounts. IgE responses and memory crucially protect against parasites and toxic components of venoms, conferring selective advantages and explaining their conservation in all mammalian species despite a parallel broad spectrum of IgE-mediated immunopathology. Long-term memory of sensitization and anaphylactic responses to allergens constitute the dark side of IgE responses, which can trigger multiple acute or chronic pathologic manifestations, some punctuated with life-threatening events. This Janus face of the IgE response and memory, both necessary and potentially dangerous, thus obviously deserves the most elaborated self-control schemes.

Highlights

B cells are specialized in immunoglobulin (Ig) selection and production, the development of which implies several phases
IgE levels peaked around 1 week after induction and while IgE+ B-lymphocytes rapidly vanished from lymphoid tissues after a few days independently of any B cell receptor (BCR) cross-linking, secreted IgE levels persisted for months, indicating that long-lived IgE+ plasma cells (PCs) survived [64]
Membrane IgE expression strongly affects lymphocyte phenotype and we suggest that evolution selected multiple mechanisms to restrict IgE responses

Summary

B Cell intrinsic Mechanisms Constraining ige Memory

Reviewed by: David Holowka, Cornell University, United States Gregory C. University of Texas at Austin, United States. Regardless of the immunoglobulin class produced, these cells can ensure longlasting protection and long-lasting immunopathology, requiring tight regulation of their generation and survival. Long-term memory of sensitization and anaphylactic responses to allergens constitute the dark side of IgE responses, which can trigger multiple acute or chronic pathologic manifestations, some punctuated with life-threatening events. This Janus face of the IgE response and memory, both necessary and potentially dangerous, obviously deserves the most elaborated self-control schemes

INTRODUCTION

DISCUSSION

CONCLUSION