Abstract
Antigen receptors have a dual role on the surface of B lymphocytes, namely the binding and internalization of antigens and the activation of the antigen-recognizing B cell. The structural requirements for internalization are still a matter of controversy; but as far as signalling is concerned it is becoming increasingly apparent that the antigen receptor is functionally divided into the ligand-binding immunoglobulin (Ig) molecule and the signal -transducing Ig-α/Ig-β heterodimer. This knowledge has been exploited to design variant antigen receptors which combine both functions in a single molecule.
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