Abstract
Background B cell activating factor (BAFF) is a member of the tumor necrosis factor superfamily and an important regulator of peripheral B cell survival, maturation and immunoglobulin class-switch recombination. Many studies suggest that BAFF might be a new mediating mechanism in foodrelated inflammation. Higher levels in non-atopic compared with atopic patients, and no correlation between BAFF and IgE, suggest that BAFF might be particularly involved in non-IgE-mediated reactions [1]. According to Finkelman there are 2 pathways of systemic anaphylaxis: antigens can cause systemic anaphylaxis in mice through the classic pathway by cross-linking IgE bound to mast cell FceRI, stimulating histamine and PAF release, or the alternative pathway by forming complexes with IgG that cross-link macrophage FcgRIII, stimulating only PAF release [2]. The aim of this study is to evaluate the correlation between BAFF and PAF in non-atopic subjects.
Highlights
B cell activating factor (BAFF) is a member of the tumor necrosis factor superfamily and an important regulator of peripheral B cell survival, maturation and immunoglobulin class-switch recombination
We measured the concentration of BAFF and PAF in the serum of 64 patients (45 females and 18 males, age 44.94 ± 8.51)
There is statistical evidence of correlation between BAFF and PAF based on the results of a Kendall correlation test (p < 0.0001)
Summary
B cell activating factor (BAFF) is a member of the tumor necrosis factor superfamily and an important regulator of peripheral B cell survival, maturation and immunoglobulin class-switch recombination. Methods We measured the concentration of BAFF (ng/ml) and PAF (ng/l) in the serum of 64 patients (45 females and 18 males, age 44.94 ± 8.51).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
