Abstract
B cell abnormalities have recently been described in adults with the Acquired Immunodeficiency Syndrome. Immunological profiles were performed in 19 children with AIDS or its prodromal stage. Opportunistic infections in AIDS patients included disseminated cytomegalovirus, invasive candidiasis, pneumocystis carinii, pneumonia and systemic mycobacterium avium intracellulare. Hypergammaglobulinemia was documented in 6 of 7 children with AIDS and in all prodromes specific antibody responses to tetanus immunization were extremely low or undetectable in 5 of 6 prodromes and in 4 of 5 children with opportunistic infections. Mitogenic responses to phytohemagglutinin were normal in 6 of 7 AIDS infants and 11 of 12 prodromes. Pokeweed mitogen responses were depressed or absent in all patients with prodrome and in 6 of 7 with AIDS. The combination of hypergammaglobulinemia, poor specific antibody responses and depressed pokeweed mitogen responses suggest that B cell abnormalities are found in childhood AIDS, and are similar to those found in adults with the syndrome. Supported by NIH Grant Number: 1 U01 AI 20671-01
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